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Both early and late-onset AD are dominated by genetic mutations on chromosome 1, 14, 21, and chromosome 19q13, respectively [3]

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10.1016/j.neuint.2008.09.012 Neurochem

This delayed activation of the transcription factor is caused by the temporal inactivation of Tpx1 by high doses of peroxides, which accumulates with its peroxidatic Cys in the sulfinic acid form

The stilbene derivatives (RSV, pterostilbene, and trimethoxystilbene) share structural similarities that contribute to their comparable molecular targets, while compounds like CDDO and curcumin exhibit particularly potent effects through simultaneous targeting of multiple pathways