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Ator2 is located between the S1 and S4 helices, and its dihydroxy heptanoic acid group forms an ionic interaction with Arg4824 in the S4S5 linker

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In a mouse model of FA-induced AKI, Fer-1 significantly restored renal function, but apoptosis inhibitors were not effective, suggesting a dominant role for ferroptosis in FA-induced AKI [136, 163]