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DSIP is found in both free and protein-bound forms in the hypothalamus, limbic system, and pituitary gland, as well as in peripheral organs including the gut secretory cells, pancreas (where it co-localises with glucagon), and plasma with brain and plasma DSIP concentrations showing a marked diurnal variation that correlates with circadian rhythm in humans, with levels lowest in the morning and higher in the afternoon

Studies suggest its fat-metabolism effects are not directly mediated via 3-adrenergic receptors, though it may increase 3-receptor expression, potentially improving lipolytic sensitivity over time

For individuals needing only B12 replenishment, shots deliver strong value

PubMed PMID: 10730193

The consequences can be as severe as triggering autoimmune diseases or compromising your body's ability to fight infections