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Microglia, as the primal phagocytic cells of the CNS, are the main elements responsible for this event

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(2) Minimizing the toxicity of complex nanostructures to prevent or reduce the additional side effects of nanocarriers, such as cardiac, renal, and hepatic function damage, as well as damage to the nervous system caused by crossing the bloodbrain barrier

Medicine (Baltimore) 98:e16421