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Gastrointestinal side effects comparison Retatrutide has a notably higher GI side effect burden at maximum doses

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Both semaglutide and tirzepatide can lead to some muscle loss if weight is lost quickly without adequate protein intake or resistance training

The result suggested a significant decrease in the extent of coronary plaques with low-attenuation area (a type of vulnerable plaques prone to rupture) (99, 100) with aged garlic extract compared to placebo, but no differences in total plaque volume and proportions of non-calcified plaques and dense calcium were found between treatment and placebo groups (98)