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PMC 4555142

In other words, scanning microcalorimetry is a technique that is capable of revealing folded polypeptide chains without showing preference for special structural features, thereby serving as a macroscopic indicator of folding (Privalov, 1979)

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Upon cleavage, the resulting soluble Jagged engages with Notch receptors, instigating a signaling cascade that impacts diverse cellular processes, including proliferation