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10.1016/j.clineuro.2021.106651 77

Prednisone is a short-acting corticosteroid medication with anti-inflammatory and immunosuppressive properties

This means your fourth dose might come up slightly short unless you account for dead-space volume or use a low dead-space syringe

As a proof of concept, disruption of the regulatory loop linking p53, the cell cycle, and clock genes has been correlated to cancer in mouse models 38