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Questa soppressione di vitale importanza nelle ferite croniche e nell' invecchiamento cutaneo (inflammaging) , dove l'infiammazione persistente degrada la matrice extracellulare e impedisce la corretta riepitelizzazione

This cellular demise can subsequently diminish ECM synthesis, which in turn, exacerbates the degradative changes within the IVD microenvironment, perpetuating a cycle that further compromises the viability of NPCs

Cycloxygenase-2 (Cox-2) catalyzes the metabolic switch of arachidonic acid to prostaglandins, which inspires Cox-2s pro-inflammatory and tumor-promoting actions

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