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Fungal toenails are difficult to treat because the fungus isnt just in the toenail, but underneath in the nail bed

High levels of intracellular calcium from high frequency stimulation activates protein kinases, which leads to increased conductance of AMPA receptors and insertion of AMPA receptors in the cell membrane

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Conclusion: Severe axial symptoms, low drug improvement rates of axial symptoms, high proportion of gait, and low gait improvement rate can suggest PSP