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While HE staining showed no overt inter-group differences, RT-qPCR analysis revealed a significant downregulation of genes associated with the intestinal barrier (ZO-1, Occludin, Claudin-1, Claudin-4) in the Model group compared to the Control group

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Bratlie MS, Johansen J, Sherman BT, Huang DW, Lempicki RA, et al

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This polymorphism impairs the lipase activity of adiponutrin and impairs TG hydrolysis, leading to an accumulation of TG in hepatocytes and consequently to steatosis