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That sudden return of circulation, in effect, a shock to the system, is known to cause a surge of inflammation and oxidative stress, that can actually make things worse

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2024 Sep 25;12(10):265

Franz diffusion cell studies comparing free GHK-Cu versus liposomal preparations document 5-fold greater dermal concentrations and 3-fold higher retention times for liposomal formulations

The highest concentration of neutralizing antibodies is reached 7 days after dose 2 in younger adults and 14 days after dose 2 in older adults