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In the cytosol, the cycle leads to serine synthesis due to the very high NADPH/NADP + ratio since NADP is the coenzyme of cytosolic MTHFD1

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it increases glucose-dependent insulin synthesis and in vivo secretion of insulin from pancreatic beta cells in the presence of elevated glucose

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It may be because of the short treatment course in our study (50 2 days) or continuing of FM medications such as duloxetine or tricyclic antidepressants in the study time which could attenuate the vitamin B12 effect