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Interindividual variability using the exponential model was estimated for K p,R and R kp , and sex and surgical treatment were tested in the covariate analysis using likelihood ratio tests

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Ave, Cornelius, OR, USA), controlled with proper stirring speed (100 rpm) and temperature (37 0.5 C), was used to study the in vitro release, whereas for dissolution studies a simulated gastric fluid (pH 1.2) and an intestinal fluid (pH 6.5) environment was used for 2 and 48 h thereafter, respectively

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