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In fact, NRF2 deletion causes an increase in OS and cellular death both in vitro and in vivo [137, 138]

Glutathione Conjugation : Glutathione, a tripeptide composed of glutamate, cysteine, and glycine, is attached to the substrate molecule by glutathione S-transferase (GST) enzymes

however, those who present with hepatic failure have a mortality rate of 20% to 40%

Toxins, on the other hand, could be either exogenous (found in the environment) or endogenous (produced by the body)

Notably, in breast cancer, BMS-777607 (a RON tyrosine kinase inhibitor) can increase resistance to cytotoxic chemotherapy drugs, including Dox (31)