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Transfusion-dependent -thalassemia patients may experience brain iron overload, potentially leading to cognitive impairment, in contrast to non-transfusion-dependent patients [43]

Thus, as data about the SSZ-sensitivity of the cystine uptake were not presented for days 100 and 130, the lack of differential cystine uptake found in this study at the older ages might rather be a consequence of decreased EAAT activity

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