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Immunopharmacology 47 , 127162 (2000)

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The immune system, like the other systems, requires many nutrients to function

(13) was negative, but the measurement of AGE was in skin, which not be reached by a significant concentration of these nutrients (vs the heart and kidneys, thru' which they would of course travel in the blood when they're taken on an empty stomach) (tho' (11) did find reductions in hexosyllysine), and their conclusion was (reasonably) that "treatment may need to continue for more than 1 year before clinical status improves." [ Edit: nixed the arginine, due to concerns raised by viveutvivas ]

Methylation is such an important and complex part of our metabolism, it can be tricky because addressing it can be beneficial to one part of the body while aggravating symptoms in another area