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The 24-h Uox values for three of the five patients who received 1.5 mg/kg of DCR-PHXC reached near-normalization levels at one or more postdose time points, and their mean maximal 24-h Uox reduction was 51% (range: 2872%)

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Pharmaceutical Packaging Configuration: 600mg/ 10 /box Stability: 36-month shelf life (40/75%RH validated) Storage: Store below 25, protected from light Compliance: 21 CFR Part 211 packaging standards Professional Usage Guide Reconstitution: Dissolve with pH 6.80.2 solvent (30s dissolution) Administration: IM/IV injection per patient condition Regimen: 1 weekly 6 weeks Compatibility: Can be co-administered with 10% vitamin C (98.7% absorption rate) Safety: Phase III: 0.33% AE incidence (n=300) Medical Advisory & Disclaimer Notice: For licensed practitioner use only

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10.1113/jphysiol.2003.039693 115 OuX.LvW