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A phase 1a/1b trial of CSF-1R inhibitor LY3022855 in combination with durvalumab or tremelimumab in patients with advanced solid tumors

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Carbon tracing indicates that one-third of the carbon in the TCA cycle metabolites of M2 macrophages derives from glutamine, which fuels the immune system [281], and serves as an anti-inflammatory metabolite to maintain M2 differentiation through the uridine diphosphate N -acetylglucosamine (UDPGlcNAc) pathway and glutaminolysis-derived -KG [16, 281, 282]