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Additionally, unmodified PLGA nanoparticles are cleared rapidly by the spleen and liver through the reticuloendothelial system (RES), shortening their circulation time and therapeutic window 99

Key metabolites of the kynurenine pathway (KP), such as kynurenine (KYN), act as agonists for the aryl hydrocarbon receptor (AHR)

10.1080/14728214.2018.1527899 [DOI] [PubMed] [Google Scholar] 427.Hollister, A

IV hydration may help support fluid replenishment after workouts, sports, heat exposure, or physically demanding routines for eligible patients

To induce mitochondrial mistranslation, we used the peptide mimetic actinonin (ACT) resulting in the accumulation of mistranslated, membrane-inserted mitochondrial proteins causing subsequent membrane potential loss 16,17,18,19,20,21