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This is the first paper describing a small-molecule direct AMPK activator

J R Stat Soc Series B Stat Methodol 57:289300 Bentayeb K, Batlle R, Sanchez C, Nerin C, Domeno C (2008) Determination of bile acids in human serum by on-line restricted access material-ultra high-performance liquid chromatography-mass spectrometry

One proposed generalizable strategy involves using DNA fragments recognized by transcription factors as targeting elements, which are linked to E3 ligase ligands to induce ubiquitination and subsequent degradation of transcription factor-DNA complexes (228)

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In most cases, the evaluation turns up a manageable or benign explanation