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M2-like TAMs promote tumor angiogenesis by producing pro-angiogenic growth factors (VEGF, EGF, FGF family, and PDGF-b), angiogenic CXC chemokines (CXCL8/IL-8 and CXCL12, also known as SDF-1), and angiogenesis-associated factors (TGF-b, TNF-, and thymidine phosphorylase) 51,52

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Each component targets distinct aspects of immune function: inflammation control, adaptive immunity enhancement, and innate antimicrobial defense

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