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In the simplest caseand the most useful in designing drug dosage regimensthe body may be considered as a single compartment (as illustrated in Figure 32 B) of a size equal to the volume of distribution (V)

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20 It also delivers a cardioprotective effect as well as anti-inflammatory and anti-atherothrombotic effects, 2125 reducing the risk of liver cancer in a dose-dependent manner 26 with a recent umbrella review of meta-analyses and systematic reviews finding strong associations between metformin use and reduced pancreatic and colorectal cancer risk