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We refer to the phenomenon whereby subjects become more resistant to permanent hearing loss following conditioning exposures as "acquired resistance to noise." The conditioning and ARN phenomena appear to be part of a general response of the mammalian auditory system, because similar results have been reported for guinea pigs, rabbits and in terms of TTS, for humans as well

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In vitro pull-down assays further confirmed that LRP1 directly interacted with ECM1, as determined using western blotting (Fig