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Comment: Several commenters supported the proposal to codify the current process for the treatment of multiple data submissions for a clinician from separate organizations in the quality and improvement activities performance categories, which uses the highest score when multiple data submissions are received from separate organizations

For each of our 10 variable groups (Supplementary Table 5) we optimized xgboost models using fivefold cross-validation and two sequential hyperparameter grids searches with early stopping (972 different parameter combinations for each feature group in total) to predict mean-centered and unit variance-scaled (regularized) TMAO levels in the left-out group using root-mean-square error (RMSE) to evaluate model outcomes

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Approaches to the evaluation of lip hyperpigmentation

HSCs are located in the perisinusoidal space of the liver and are mainly responsible for storing vitamin A