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Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia

The cause and effect of errors in the control mechanisms of GCL are slowly being unravelled by researchers and is the subject of several excellent reviews [2-6]

Furthermore, SCFAs upregulate the expression of Foxp3, a key transcription factor for regulatory T cells, through HDAC inhibition (208, 209), promoting Treg differentiation and suppressing the production of pro-inflammatory cytokines (210)