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It is a living organ with a complex structural framework made primarily of collagen and elastin fibers embedded in a gel-like substance called the extracellular matrix

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92 Endoplasmic reticulum stress treatment mainly improves the symptoms of UC by regulating endoplasmic reticulum function and reducing the abnormal accumulation of intracellular proteins, thereby inhibiting the inflammatory response of cells

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Although this adverse effect is typically reversible upon treatment cessation, it remains a critical safety concern