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Supplemental Figure Acknowledgments We express our thanks to professor Huiliang Li (Wolfson Institute for Biomedical Research, UCL) for his helpful discussion of the project, critical reading and kind suggestions to the manuscript

Yes, storage protocols differ significantly

In individuals with knee osteoarthritis, the level of hyaluronic acid decreases, leading to increased friction, pain, and stiffness

Cumulatively, these studies indicate that the therapeutic performance of CQDs in photodynamic and photothermal applications is fundamentally governed by synthesis-driven modulation of photophysical properties rather than by the carbon core alone

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