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Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly

While each peptide stimulates GH release through different receptor interactions, their combined effects may extend beyond simple hormone elevation

Believe me when I say this was the simplest explanation I could find: It acts on somatotropes to increase GH biosynthesis and secretion After release from the hypothalamus, GHRH binds to the GHRH receptor predominantly located on the pituitary somatotrope

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