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For example, the microRNA (miR)-127-3p/MAPK/AKT/mechanistic target of rapamycin (mTOR)/p70S6K axis has been shown to simultaneously stimulate tumor cell autophagy and polarize macrophages toward an M1 phenotype (6)

Specific mechanisms under investigation include critical pathways involved in the generation of and protection against oxidative stress

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It showed that APAP metabolites can induce neurotoxicity like oxidative stress, glutathione depletion, and endocrine disruption

e1e9 Wegmann M, Fehrenbach H, Fehrenbach A, Held T, Schramm C, Garn H, Renz H 2005 Involvement of distal airways in a chronic model of experimental asthma