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the avenanthramides are an extract of one or more of Avena sativa, Pieris brassicae, Pieris rapae, or Dianthus caryophyllus

Later, pharmacological studies also suggested that TRPM7 mediates apoptotic neuronal death caused by brain ischemia through modulation of CaMKII, calmodulin, and calcineurin (Turlova et al., 2021)

Integrated preclinical to first-in-human to indication-specific randomized clinical trials (RCTs) would be ideal candidates to combine mechanistic readouts (local drug/metabolite concentration, biofilm imaging, single-cell viability) with clinical readouts and, in advanced preclinical studies, local drug/metabolite concentrations

Examples include high-dose vitamin A or retinoids (which can be hepatotoxic in excess), green tea extract catechins (associated with rare cases of liver injury), kava, or high-dose niacin

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