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Certainly, our study should provide insight into elucidating the mechanism of chemotherapy-induced POI or idiopathic POI, and the dietary serine supplementation might be a simple therapeutic strategy for preventing and curing ovarian hypofunction clinically

NAFLD includes the benign NAFLD and the more severe non-alcoholic steatohepatitis (NASH), which carries a higher risk of progression to severe liver disease (15, 16)

The supernatant was transferred to LCMS vials, and the pellet was lysed by 20 mM NaOH and protein levels were detected for normalization

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The FVIIAg and FXAg levels (ng/ml) were normalized to 1 10 6 cells, and the ratio of organoid/primary hepatocytes was calculated