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Plant J 44:653668 Sattelmacher B (2001) The apoplast and its significance for plant mineral nutrition

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1.2 Pathophysiological role of Piezo1 in the CNS Recent studies have shown that mechanical forces determined neural development and function ( A previous study (Pathak et al., 2014) showed that traction-mediated Piezo1 activation triggers inward calcium flow and directs neural stem cell lineage selection toward a neuronal phenotype than the astrocyte phenotype

It is predictable that TTFD would be the best choice since it has beneficial effects both inside and outside the brain and it certainly needs to be explored and researched further as a very valuable therapeutic agent

References Murphy, MM, Molloy, A, Ueland, PM et al