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Emerging therapies aim to restore or modify neural pathways, with drugs like NitroSynapsin addressing hyperexcitability and leucovorin correcting folate transport issues

The aged tendon group showed markedly lower SOD2 mRNA levels and diminished SOD2-positive staining in tenocytes, which coincided with increased oxidative damage, mitochondrial swelling, and disruption of cristae structure under transmission electron microscopy (Uehara et al., 2022)

MicroRNA-34a-5p promotes joint destruction during osteoarthritis

Glutathione serves as a first line of defense by preventing free radicals from forming and neutralizing those that do before they can damage healthy cells