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Fredriksson L, Wink S, Herpers B et al (2014) Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity

AAs are derived from tyramine and are unique to the Amaryllidoideae family, where they contribute to plant defense under abiotic and biotic stress (Liyanage et al

doi: 10.1016/j.matdes.2023.112231 123 LoiseauA.AsilaV.Boitel-AullenG.LamM.SalmainM.BoujdayS

In addition, a GSH/GSSG assay kit was used in this study, which is capable of accurately quantifying GSH/GSSG in cells by utilizing the enzymatic reaction between 5, 5-dithiobis-2-nitrobenzoic acid (DTNB) and glutathione reductase (GR)

When ROS increases, the synthesis of mitochondrial fusion-related proteins will be inhibited, thus promoting mitochondrial fission, which in turn may lead to more ROS production and severe mitochondrial dysfunction