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12 Specifically, NAC is thought to affect thioredoxin expression, which regulates DNA binding of NF-kB and glutaredoxin expression that is responsible for detecting changes in the redox state of GSH

Considering ROS and Ca 2+ are also core signaling modulators in various neutrophils responses, it remains an intriguing question how neutrophils prioritize downstream fates, such as phagocytosis, degranulation or releasing NETs, upon encountering the pathogens

While human studies are ongoing, preclinical data highlight its role in reducing inflammation and promoting tissue regeneration

It has been reported that applying the ES on end-to-end coaptation of the nerves or even auto-transplantation could improve the result of nerve regeneration 26,27

Dev Cell 56:881905