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Findings from the global burden of disease study 2021

Butyrate-induced macrophages also exhibit higher levels of AMP, an inducer of AMP-kinase (AMPK), which inhibits mammalian target of rapamycin (mTOR), the master regulator protein kinase of autophagy, which is associated with cancer, insulin resistance, and other diseases (Schulthess et al., 2019

Sounds great until you see that it was a retrospective chart review with no control group

Measurement of GR activity The activity of GR was determined as described by Esterbauer and Grill (1978) with modifications

Establishment of Iba1-Cre transgenic mice The Iba1-Cre transgenic mice were generated with a standard transgenic method