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As precision medicine approaches advance, targeting proteostasis networks holds substantial promise for preserving myocardial function, slowing disease progression and reshaping the future of cardiovascular therapeutics

It has drawn interest for its association with pathways involved in energy utilization and metabolic regulation, particularly within skeletal muscle research models

Phosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinsons disease

Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus

Since rodent and human -cells express DA D 2 -like receptors 22,23 , APDs may also directly target -cell D2R/D3R to raise glucagon and drive hyperglycemia, further contributing to insulin resistance