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STING Pathway Inhibition: In aging models, it has been shown to shutdown the cGAS-STING inflammatory response, protecting vital organs like the kidneys from age-related decline

The V-ATPase-ATG16L1 axis was also shown to initiate intracellular clearance of bacteria (163)

It has been shown to work for other types of tendon injury, such as tennis elbow and patellar tendinopathy

[1] [3] This condition is typically confirmed through blood tests for anti-intrinsic factor antibodies

[] Conversely, PTEN induced kinase 1 (PINK1) phosphorylation similarly triggers Parkin-dependent MFN2 ubiquitination, which inhibits fusion by promoting MFN degradation, thus promoting fission and mitophagy