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The challenges faced by the nanomaterials in the process of clinical translation are highly complex due to the fate of nanomaterials in vivo, specifically stability issues as it is exposed to various biological systems, safety/toxicity issues due to bio-accumulation of non-degradable materials, and so on

Patients who are experiencing this problem also often have problems with their digestion

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Establishing comprehensive profiles of biodistribution, biodegradation, clearance, and long-term immunological consequences is the prerequisite for solving this problem

Therefore, the development of kidney disease in people with high-risk alleles may require additional factors, known as secondary hits, such as infections, environmental factors (heavy metals), infections, and the microbiome, among others