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This reveals a critical principle: for predicting the clinical outcome of protein-binding drug interactions, understanding the drug's extraction ratio is more important than simply knowing its degree of protein binding

288,289 In one study, 44% of untreated patients but 38%, 28% and 9% of patients treated with CRS, CBT-I, and CBT-I + CRS, respectively, experienced clinically significant worsening of depressive symptoms during a 1-year follow-up period

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Specifically, lysine lactoylation was decreased in HF-SAAR WT mice compared to WT HF-CTRL (Fig