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Because Avastin is used off-label, and its makers do not plan to seek approval of the drug for AMD, it has not been as thoroughly investigated as either Lucentis or Macugen (Gillies 2006)

A prospective study of transsulfuration biomarkers in autistic disorders

Heseker H

Following dosage recommendations did not show serious adverse side effects when taken for less than 12 months, but included stomach upset, breath and urine odour, and seizures in some cases