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Finding the "best" set of features to build a predictive model is a complex combinatorial problem and available methods are generally classified into two categories: filtering methods (those which rank individual features according to some criteria) and more involved wrapper algorithms, which use classification methods directly to evaluate a particular set of features

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Thus, this increase in S-5-HT from before to after L-carnitine was about 8-fold in CFS and 6-fold in hypothyroidism