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Several therapeutic targets have been identified, including osteopontin, cysteinyl leukotriene 2 receptor, the opioid receptor antagonist -funaltrexamine, and PPAR and RXR agonists

The same principle likely applies here

Robust human mechanism data are not yet available

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PPAR antagonists can block the increase of PPAR DNA binding activity and antioxidant enzymatic activities (SOD), inhibiting the protection of PPAR activation in OGD-exposed neurons 137