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Future studies should prioritize elucidating the pharmacological actions and clinical relevance of individual PRLMs, particularly RvD1 and LXA4, in CF

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For example, phage OMKO1 infects PsA and selects for evolved phage resistance that coincides with reduced multidrug efflux (Mex) pump function to achieve reduced antibiotic resistance 9 , a trade-off previously exploited in a clinical case of phage therapy 10

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doi: 10.1016/j.biomaterials.2018.01.018

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Human evidence to date suggests NAD+ precursors appear to be safe: Decades of research on NR and other NAD+ precursors have not shown increased cancer risk or major safety concerns in humans, though research is ongoing

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