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Many patients choose the compounded route specifically because the predictable cash price is lower than the branded copay over a year of treatment

Absorption is rapid regardless of route (peak plasma levels within 3090 minutes), and theres no evidence that route of administration affects NNMT inhibition efficacy

We recently reported that NNMTi treatment combined with a low-fat, or lean, diet (LD) returned systemic adiposity and liver pathologies of obese animals to the adiposity and liver pathology levels of LD controls

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Al Ani A, Qureshi PAAA, Bollineni VR Cureus 2023