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However, MPs and NPs inhibit production of antioxidant enzyme transcription factors or decrease activity of antioxidant enzymes, which in turn inhibits ROS metabolism and increases mitochondrial membrane potential resulting in an increase in mitochondrial permeability and ROS production, thus increasing mitochondrial ROS production

The regulation of iron absorption

This creates an interplay of factors that require examination

[DOI] [PubMed] [Google Scholar] 26.Kim J

ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50