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Furthermore, the relative abundance of Akkermansia , a genus positively associated with improvements in obesity-related metabolic issues 60 , was increased in the vehicle-treated group that underwent diet switch relative to the WD control group, suggesting a potential for distinct microbiome-mediated mechanisms of weight loss subsequent to diet switch from those of diet switch in combination with 5A-1MQ treatment

As such, an effective treatment would be expected to augment striatal synaptic connectivity, protect SN neurons from underlying death inducers, and ideally stimulate the replacement of lost SN neurons from preexisting pools of neural stem cells

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