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References ACS Chemical Biology (2023) Synthetic ERR// Agonist Induces an ERR-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Journal of Pharmacology and Experimental Therapeutics (2024) A Synthetic ERR Agonist Alleviates Metabolic Syndrome Circulation (2024) Novel Pan-ERR Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism and Mitochondrial Function American Journal of Pathology (2023) Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

In this context, the peptidase, DJ-1 could have a prominent role because it possess reactive cysteines and is a modulator of mitochondrial dynamics and mitophagy (Thomas et al., 2011)

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