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In chronic pain and depression, chronic exposure to stress is a common factor that may produce long-lasting changes (i.e., maladaptive neuroplasticity) in highly sensitive brain areas such as the prefrontal cortex and the hippocampus and in their functional connections, which may underlie the cognitive and behavioral impairments accompanying these conditions (Teffer and Semendeferi, 2012

The ion transport variants in our study are almost all missense variants leading to single amino acid substitutions in cation channel genes

HDAC inhibitors are organic compounds that inhibit histone deacetylation, exerting protective effects on the kidney by suppressing inflammatory responses and regulating cellular processes, including apoptosis and autophagy

Alzheimers-afflicted brains show a 25% to 40% reduction in carnitine acetyltransferase, a brain enzyme that works with L-carnitine & acetyl-L-carnitine

Honjo 2014