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Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice

The tertiary structure of Apo M consists of antiparallel -barrel sheets surrounding the internal ligand binding pocket, flanked by an external -helix 14,40,41

10.1159/000028326 Pharmacology 11 ArakawaJ.HaraA.KokitaN

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DZ: dark zone LZ: Light zone Tfh: Follicular helper T cells PB: Plasmablast FDCs: Follicular dendritic cells LLPC: Long-lived plasma cells Ggt5: Gamma-glutamyltransferase-5 CB: Cannabinoid 2-AG: 2-Arachidonoylglycerol EBI2: EpsteinBarr virus-induced molecule 2 EF: Extrafollicular MZ: Marginal zone BLR1: Burkitt's lymphoma receptor 1 IBD: Inflammatory bowel disease BTK: Bruton's tyrosine kinase RA: Rheumatoid arthritis SLE: Systemic lupus erythematosus SPC: Sphingosylphosphorylcholine LPS: Lipopolysaccharide EAE: Experimental allergic encephalomyelitis NMOSD: Neuromyelitis optical spectrum disorder CNS: Central Nervous System ASCs: Antibody-secreting cells BP: Bullous pemphigoid TLS: Tertiary lymphoid structure BCR: B-cell receptor pSS: Primary Sjogrens syndrome AITD: Autoimmune thyroid disease HT: Hashimoto thyroiditis GD: Graves disease ABCs: Age-associated B cells G2A : / G2A gene knockout References Du W, Han M, Zhu X, Xiao F, Huang E, Che N, et al